Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response
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چکیده
منابع مشابه
Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response
Mismatch repair proteins modulate the cytotoxicity of several chemotherapeutic agents. We have recently proposed a "death conformation" of the MutS homologous proteins that is distinguishable from their "repair conformation." This conformation can be induced by a small molecule, reserpine, leading to DNA-independent cell death. We investigated the parameters for a small reserpine-like molecule ...
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ژورنال
عنوان ژورنال: Journal of Nucleic Acids
سال: 2010
ISSN: 2090-021X
DOI: 10.4061/2010/162018